The Prevention Playbook

A clinical implementation guide designed for healthcare professionals involved in modern Sexual Health and HIV prevention care.

The Prevention Playbook bridges the gap between official CDC/FDA guidance and real-world clinical operations by translating prevention science into practical workflows clinicians can actually implement. Rather than functioning as a simplified overview of PrEP medications, this resource focuses on diagnostic safety, operational decision-making, patient selection, documentation protection, and long-term prevention strategy implementation.

Built for clinicians working in sexual health, HIV prevention, primary care, urgent care, and community-based prevention programs, the playbook provides a structured approach to oral PrEP, event-driven PrEP, same-day rapid-start workflows, and long-acting injectable prevention including APRETUDE and YEZTUGO.

This resource emphasizes not only what to prescribe, but how to safely operationalize prevention systems while reducing diagnostic errors, resistance risk, workflow failures, and medico-legal vulnerability.

Inside the playbook:

• Foundations of modern HIV prevention practice

• Same-day oral PrEP implementation workflows

• FTC/TDF vs FTC/TAF decision frameworks

• Event-driven (2-1-1) PrEP implementation and limitations

• Long-acting injectable PrEP operational systems

• APRETUDE clinical implementation guidance

• YEZTUGO implementation workflows and dosing logic

• HIV diagnostic escalation strategies

• Missed-dose and delayed-dose management

• Documentation protection frameworks

• Real-world counseling language and clinical pearls

• Publication-grade implementation algorithms and workflows

Designed with both clinical realism and operational safety in mind, The Prevention Playbook focuses heavily on HIV diagnostic discipline, result reconciliation, follow-up accountability, and resistance prevention; areas frequently underemphasized in standard educational materials.

This is not a patient education resource. It is a clinician-facing implementation system intended for licensed healthcare professionals seeking a more structured, defensible, and operationally mature approach to HIV prevention delivery.

Format: Digital publication (PDF)
Audience: Licensed clinicians, HIV prevention providers, PrEP specialists, sexual health programs, nurse practitioners, physician assistants, physicians, and healthcare educators.

Author:
Dr. Kensy Chavez, MBBS, DNP, APRN, FNP-C.
Alejandro L. Gonzalez Perez, MSN, APRN, FNP-C

Disclaimer:
This publication is intended for educational and professional development purposes only and does not replace CDC guidance, FDA-approved prescribing information, institutional protocols, or independent clinical judgment.